Bioactive Small Molecules
Cayman Chemical ANTIBODY SIB 1757 25mg
An antagonist of mGluR5a; selectively inhibits glutamate-induced calcium release and quisqualate-induced phosphoinositol accumulation in fibroblasts expressing human mGluR5a (IC50s = 0.37 and 3.1 µM, respectively) over mGluR1b-expressing fibroblasts (IC50s = >100 µM for both); selective for mGluR5a over mGluR2, mGluR3, mGluR4a, mGluR6, mGluR7b, mGluR8 (IC50s = >100 µM for all) as well as AMPA, kainate, and NMDA receptors (IC50s = >30 µM for all); inhibits (S)-3,5-DHPG-induced phosphoinositol accumulation in isolated neonatal rat hippocampus and striatum (IC50s = 5.2 and 10.1 µM, respectively); intrathecal administration increases the paw withdrawal threshold in a rat model of spinal nerve ligation-induced neuropathic pain at 0.01 UG/animal
Cayman Chemical ANTIBODY AC-262536 5mg
A SARM (Ki = 5.01 nM); an androgen receptor partial agonist (EC50 = 1.58 nM in a luciferase assay); selective for the androgen receptor over a panel of 47 additional human nuclear receptors at 10 µM; inhibits dihydroxytestosterone-induced proliferation of LNCaP prostate cancer cells at 0.1 and 1 µM; reduces plasma luteinizing hormone levels and increases levator ani muscle weight in castrated rats at 3, 10, and 30 mg/kg; exhibits smaller increases in prostate gland and seminal vesicle weight compared with testosterone in the same model
Cayman Chemical BleomycInsulfate 5mg
A glycopeptide antitumor antibiotic that produces single and double-strand DNA breaks in tumor cells to interrupt their cell cycle; has been used for the treatment of Hodgkin’s lymphoma in combination with doxorubicin, squamous cell carcinomas, testicular cancer, as well as in animal models of pulmonary fibrosis
Medchemexpress LLC GNE-317 | 1394076-92-6 | 98.8% | 100 MG
GNE-317 is a PI3K/mTOR inhibitor that can cross the blood-brain barrier (BBB). It is an oxetane derivative of GDC-0980, synthesized to reduce substrate affinity for efflux transporters. While GNE-317 shows greater delivery and enhanced therapeutic targeting efficacy compared to GDC-0980, it showed limited efficacy in inducing cell death in GL261 cell lines in vitro and was not found effective in vivo in GL261 tumor models.
- PI3K/mTOR inhibitor
- Can cross the blood-brain barrier (BBB)
- Oxetane derivative
- Greater delivery and enhanced therapeutic targeting efficacy
Apexbio Technology LLC Belinostat (PXD101), 50mg. Cas: 414864-00-9 MFCD: MFCD08064035. Hydroxamate-type HDAC inhibitor
Belinostat (also known as PXD101) is a novel and potent hydroxamate-type inhibitor of histone deacetylase (HDAC) that inhibits the activity of HDAC in Hela cell extracts with 50% inhibition concentration IC50 value of 27 nM. Other sizes are available. Please inqury us for quote.
Cayman Chemical Talaromyceson A 5mg
A fungal metabolite; active against S. epidermidis and MRSA (IC50s = 3.70 and 5.48 µM, respectively); inhibits human AChE in a cell-free assay (IC50 = 7.49 µM)
Cayman Chemical EIcosapentaenoIc AcIdodIum 5mg
EPA is an ω-3 fatty acid abundantly available in marine organisms. It is a poor substrate for COX-1.{1067} EPA has been shown to offer protection against coronary heart disease, thrombosis, ischemic brain injury, scaly dermatitis, and some inflammatory diseases.{32,208}
Cayman Chemical ANTIBODY CJ-13610 5mg
An inhibitor of 5-LO (IC50 = 70 nM for 5-LO product formation in A23187-challenged PMNLs); inhibits recombinant 5-LO in a glutathione peroxidase-dependent manner (IC50 = 300 nM); reduces levels of LTB4 and decreases mechanical hyperalgesia in a rat model of chronic inflammatory pain induced by Freund's adjuvant (3-10 mg/kg); reverses tactile allodynia and increases hind paw weight bearing in a rat medial meniscal transection model of osteoarthritic pain (0.6-6 mg/kg)
Cayman Chemical ANTIBODY BD 750 100mg
An immunosuppressant; inhibits the proliferation of primary human and mouse T cells (IC50s = 1.1 and 1.5 µM, respectively) without inducing cytotoxicity at 3.13 to 50 µM; induces cell cycle arrest at the G0/G1 phases in activated primary human T cells at 0.625, 2.5, and 10 µM; decreases cyclin D3 and Cdk6 levels in activated primary mouse T cells at 2.5 and 10 µM; reduces the proliferation of IL-2-stimulated CTLL mouse T cells (IC50 = 1.2 µM) and decreases phosphorylated Stat5 levels in the same cells at 5 and 20 µM; inhibits 2,4-dinitrofluorobenzene-induced increases in EAr thickness and EAr patch weight in a mouse model of delayed-type hypersensitivity
Cayman Chemical D-ErItadenIn 5mg
An inhibitor of SAAH (IC50 = 7 nM); inhibits growth of C. parvum parasites (MIC50 = 3 μM) without exhibiting cytotoxicity in HCT-8 cells (CC50 = >1 mM); dietary administration increases liver microsomal phosphatidylethanolamine concentration and decreases liver microsomal Δ6 desaturase activity and plasma cholesterol levels in rats at 50 mg/kg
Cayman Chemical ProstaglndIn E1 Alcohol 5mg
A non-irritant bronchodilator with relaxant activity on human bronchial muscle; binds to the mouse recombinant EP3 and EP4 receptors with Ki values of 330 and 190 nM, respectively
Medchemexpress LLC Polycarbophil | 9003-97-8 | 1 G
Polycarbophil is an orally active hydrophilic polymer. It achieves bioadhesion through hydrogen bonding between carboxyl groups and mucosal surfaces. It prolongs compound retention time and regulates compound release through its swelling properties. It is used to relieve constipation and diarrhea.
- Orally active hydrophilic polymer
- Achieves bioadhesion through hydrogen bonding with mucosal surfaces
- Prolongs compound retention time
- Regulates compound release through swelling properties
- Relieves constipation and diarrhea
- Increases apparent permeability of compounds (in vitro)
- Increases fecal weight and water content (in vivo)
- Restores fecal weight and relieves constipation (in vivo)
- Suppresses diarrhea (in vivo)
Selleck Chemical LLC Temozolomide 25mg 85622-93-1 CCRG81045, NSC 362856,TMZ
Temozolomide (CCRG81045, NSC 362856, TMZ) is a monofunctional SN-1 alkylating agent that can modify nitrogen atoms in the DNA ring and the extracyclic oxygen group, chemically converted to MTIC and degrades to methyldiazonium cation, which transfers methyl groups to DNA at physiologic pH. A DNA damage inducer in L-1210 and L-1210/BCNU cells. Temozolomide induces apoptosis and exhibits antitumor activity. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Cayman Chemical 14-nhydrodIgItoxIgenIn 5mg
A cardenolide; reduces the activity of guinea pig heart Na+/K+-ATPase by 15% at 10 µM
Cayman Chemical Secretase Inhibitor IV 5mg
An inhibitor of BACE1 and 2 (IC50s = 15 and 230 nM for human BACE1 and 2, respectively); has >500-fold selectivity for BACE1 and 2 over the aspartyl proteases renin and cathepsin D; inhibits secretion of APP (IC50 = 29 nM) in HEK293T cells transfected with a truncated human APP; inhibits formation of the Aβ peptides Aβ38, Aβ40, and Aβ42 in primary chick neurons (IC50s = 3.7, 4.7, and 4.8 nM, respectively)