Bioactive Small Molecules
Medchemexpress LLC Wnk-in-1 (compound 7) | 2125724-72-1 | 98.9% | 2MG
Wnk-in-1 (compound 7) | 2125724-72-1 | 98.9% | 2MG
Medchemexpress LLC 5-bromo-2-chloroanisole | 16817-43-9 | 98.3% | 221.48 | 50 G
5-Bromo-2-chloroanisole is a biochemical reagent. It can be used as a biological material or organic compound for life science related research.
- Suitable for life science related research
- For research use only
Medchemexpress LLC Asenapine hydrochloride | 1412458-61-7 | 99.95% | 322.23 | 1 ML
Asenapine hydrochloride (Org 5222) is an atypical antipsychotic primarily acting as an antagonist of serotonin, adrenoceptor, dopamine, and histamine receptors. It is investigated for its potential therapeutic effects in schizophrenia and bipolar disorder research, demonstrating high affinity for various 5-HT and dopamine receptor subtypes.
- Acts as an antagonist for serotonin, adrenoceptor, dopamine, and histamine receptors.
- Shows high affinity for 5-HT2C, 5-HT2A, 5-HT2B, 5-HT7, 5-HT6, α2B, and D3 receptors.
- Potent antagonist at 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT6, 5-HT7, D2, D3, α2A, α2B, α2C, and H1 receptors.
- Used in research for schizophrenia and bipolar disorder.
- May offer superior therapeutic effects on anxiety symptoms.
- Exhibits anxiolytic-like effects in mice.
Medchemexpress LLC Cyclo-(Pro-Gly) (pyrrolopiperazine-2,5-dione) | 19179-12-5 | MFCD01083707 | 99.9% | 154.17 g/mol | C7H10N2O2 | 1 G
Cyclo-(Pro-Gly) is a cyclic dipeptide (pyrrolopiperazine-2,5-dione) used as a reference standard in biochemical and pharmacological research. It is supplied as a high-purity solid and as a 10 mM solution in DMSO for laboratory assays; intended for research use only.
- High purity: 99.9% (HPLC).
- Chemical name: Cyclo-(Pro-Gly) (pyrrolopiperazine-2,5-dione).
- Cas number: 19179-12-5.
- Molecular formula: C7H10N2O2.
- Molecular weight: 154.17 g/mol.
- Available formats: solid (50 mg-10 g) and 10 mM solution in DMSO (1 mL).
- Intended use: research only; not for human or clinical use.
- Storage: follow conditions in the certificate of analysis.
Medchemexpress LLC TNG-0746132 | 2821749-57-7 | C26H22F3N7O | 25 MG
TNG-0746132 is a research-grade compound utilized in the synthesis of compounds exhibiting anticancer activity. This product is presented as a high-purity solid, typically white to off-white in color, and is strictly for laboratory use.
- High purity for reliable research applications
- Appears as a white to off-white solid
- Suitable for synthesizing anticancer compounds
- Intended exclusively for research purposes
Medchemexpress LLC NP3-562 | 2409825-32-5 | 98.2% | 437.94 | 50 MG
NP3-562 is an orally active NLRP3 Inhibitor that blocks IL-1β release in stimulated cells and in vivo models. It is suitable for acute peritonitis research.
- Orally active NLRP3 inhibitor
- Inhibits IL-1β release
- Used for acute peritonitis studies
- Demonstrates brain exposure
Medchemexpress LLC mTOR inhibitor WYE-23 | 1062169-46-3 | 99.2% | 520.58 g·mol⁻1 | C26H32N8O4 | 25 MG
WYE-23 is a potent small-molecule inhibitor of the mechanistic target of rapamycin (mTOR) with reported sub-nanomolar potency and antitumor activity. It shows moderate selectivity versus PI3Kα and is supplied as a research-grade reagent for in vitro and in vivo studies.
- Potent mTOR inhibition (IC50 0.45 nM).
- Selective versus PI3Kα (IC50 661 nM).
- Reported antitumor activity in preclinical studies.
- Molecular weight 520.58 g·mol⁻1; chemical formula C26H32N8O4.
- High purity (≈99%).
- Recommended storage: powder at -20°C; in solvent store at -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC Deferoxamine | 70-51-9 | 99.6% | 100 MG
Deferoxamine is an iron chelator that binds to Fe(III) and other metal cations, used to reduce iron accumulation and deposition in tissues. It upregulates HIF-1α levels and exhibits good antioxidant activity. This compound also shows anti-proliferative activity and can induce apoptosis and autophagy in cancer cells.
- Used in studies of diabetes.
- Used in studies of neurodegenerative diseases.
- Used in anti-cancer research.
- Used in anti-COVID-19 research.
Cayman Chemical Aristolochic Acid C, Purity: ≥95%, CAS: 4849-90-5, 5 mg
An alkaloid; inhibits the growth of LLC-PK1, P388, HT-29, and HL-60 cancer cells (IC50s = 85, 8.8, 17.1, and 40 µM, respectively)
Cayman Chemical CNX-774, Purity: ≥98%, CAS: 1202759-32-7, 1 mg
A potent, selective, and irreversible BTK inhibitor
Medchemexpress LLC AZ-3137 | 2960179-55-7 | 99.9% | 801.87 | 5 MG
AZ'3137 is an orally active PROTAC-type androgen receptor (AR) degrader with a DC50 value of 22 nM. It can degrade L702H mutant AR (DC50 of 92 nM) and inhibit cell proliferation of LNCaP, with a GI50 value of 74 nM. It can also inhibit AR signaling and tumor growth in prostate cancer mice.
- Orally active PROTAC-type androgen receptor (AR) degrader.
- Degrades L702H mutant AR.
- Inhibits cell proliferation of LNCaP cells.
- Inhibits AR signaling and tumor growth in prostate cancer mice.
- Inhibits AR signaling and cell proliferation of prostate cancer cell line LNCaP (0-10 μM; 7 days).
- Inhibits the expression of AR target genes in LNCaP cells (0.1 nM-10 μM; 24 h) and degrades AR in C4-2 and VCAP cells (0.1 nM-10 μM; 24 h).
- Inhibits tumor growth in prostate cancer mice (oral gavage (p.o.); once daily; for 10 days).
eMolecules 877950-01-1 | Medchem Express | LtaS-IN-1 | 5mg | 536984161 | HY-135813 | 427.416 | C24H17N3O5
Medchem Express | LtaS-IN-1 | 5mg | 536984161 | HY-135813 | 877950-01-1 | 427.416 | C24H17N3O5
Medchemexpress LLC Zasocitinib | 2272904-53-5 | 99.24% | 460.49 | 5 MG
Zasocitinib (NDI-034858) is a potent TYK2 inhibitor, specifically targeting the TYK2 JH2 domain with a high binding constant (Kd) of <200 pM. It also exhibits inhibitory effects on Tyk2 and JAK by targeting their JH1 domains. This compound is intended for research use only.
- Inhibits phosphorylation induction of heterodimer complex Tyk2/JAK2-mediated IL-12 effect
- IC50 value of <0.1 μM in human peripheral blood mononuclear cells
- Off-white to light yellow solid appearance
Cayman Chemical BDP9066, Purity: ≥98%, CAS: 2226507-04-4, 10 mg
An inhibitor of MRCKα and MRCKβ (Kis = 0.0136 and 0.0233 nM, respectively); selective for MRCKα and MRCKβ over ROCK1 and ROCK2 (Kis = 18.4 and 5.38 nM, respectively) and a panel of 115 additional kinases at 1 µM; has antiproliferative activity against a panel of 757 cancer cell lines (EC50s = 50 = 64 nM); inhibits the motility of SCC-12 cells; decreases average papilloma volume in a mouse two-stage model of DMBA-initiated and TPA-promoted skin carcinogenesis at 25 µg/animal
Medchemexpress LLC BMS-193885 | 186185-03-5 | 99.9% | 5 MG
BMS-193885 is a research-grade selective neuropeptide Y1 receptor antagonist used in preclinical studies of appetite regulation and metabolic disease. It is blood-brain barrier permeable, supplied as solid or as DMSO solutions, and is commonly available in small research pack sizes such as 5 mg.
- Selective neuropeptide Y1 receptor antagonist (Ki = 3.3 nM).
- High purity (99.9% by HPLC).
- Blood-brain barrier permeable, suitable for in vivo studies.
- Available as solid and as pre-made DMSO solutions for stock preparation.
- Common pack sizes include 5 mg for small-scale experiments.